Optimization and Scale-up

Optimization delivers a process which is appropriately fit-for-purpose.

Examples of Targets include.

• -Maximizing overall yields

• -Minimizing solvent volumes

• -Substitution of high-cost materials/reagents

• -Simplification of work-up and isolation procedures

• -Robustness and failure boundary determination

• -Impurity level controls

Scale-dependance studies are conducted to reveal the parameters controls required. Scale-up demonstration batches are carried out to affirm or challenge the scale-dependance understanding and prepare a process for manufacturing.