Optimization delivers a process which is appropriately fit-for-purpose.
Examples of Targets include.
-Maximizing overall yields
-Minimizing solvent volumes
-Substitution of high-cost materials/reagents
-Simplification of work-up and isolation procedures
-Robustness and failure boundary determination
-Impurity level controls
Scale-dependance studies are conducted to reveal the parameters controls required. Scale-up demonstration batches are carried out to affirm or challenge the scale-dependance understanding and prepare a process for manufacturing.