We are experienced in bringing a range of tools to bare on the challenge of developing novel routes and processes, and manufacturing enantioenriched compounds on large-scale.
We utilize enzymes, transition-metal based catalysis, organo-catalysts, auxiliary’s, classical resolution methods and chiral pool approaches.
To support the development work, a wide range of chiral HPLC, prep-LC and GC systems are utilizing. Allowing our chemists to gain insights quickly.
Sulfur Containing Compounds
We developed a unique process for the preparation of thioamides which is mild, cost-effective and scalable.
We have continued to develop our expertise in the preparation of other sulfur containing compounds including for example thiazoles, thiols, benzothiophenes and thiiranes.
Special considerations are required around safety and comfort when manufacturing sulphur containing compounds and we have established best practices.
Developing processes involving the use transition metals on production scale requires a high level of attention to details and an understanding of the factors affecting reaction performance.
The target of the challenge is to deliver a scalable, repeatable, and cost-efficient process. We have experience in delivering competitive processes for a range of TM catalyzed reactions including cross coupling, amination and borylation reactions.
Our GMP facilities includes cryogenic capabilities.
Amino Acid Derivatives
We have developed expertise in the preparation of a range of amino acid analogs, including amino alcohols, un-natural amino acids and N-Carboxy-Anhydrides NCAs.